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Beyond Amyloid & Tau: Leveraging Molecular Subtypes and Repurposed Drugs for Personalized AD Treatment

  CTAD  2024  Abstract   Title : Beyon d  Amyloi d  &  T au : Leveraging Molecular Subtypes and Repurposed Drugs for Personalized AD Treatment   Au t hor :   KJ  Lavan , Brain Matrix Alliance, Dubai, UAE Background : Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Despite decades of research, there are currently only a handful of approved drugs, and none offer a cure. Traditional drug discovery for AD has a notoriously high 99% failure rate. This highlights the urgent need for new approaches. Stratified medicine, which tailors treatments to specific patient subgroups based on their unique molecular and genetic profiles, and drug repurposing, which leverages existing medications for new therapeutic uses, are emerging as promising strategies. Methods : While there are ongoing drug repurposing efforts in AD, these studies often target the entire patient population,...
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A New Dawn for Complex Diseases: Brain Matrix Alliance at the Forefront

A New Dawn for Complex Diseases: Brain Matrix Alliance at the Forefront The Brain Matrix Alliance (BMA) is tackling some of the most challenging neurological conditions, like Alzheimer's Disease (AD), with a revolutionary approach. AD, the leading cause of dementia globally, is just one example. It afflicts millions, strains healthcare systems, and  currently [a]  lacks a cure. The disease is characterized by the buildup of amyloid-beta plaques and tau protein tangles in the brain, leading to progressive cognitive decline. Despite significant research efforts, traditional drug development for complex diseases like AD faces hurdles: Heterogeneity:  These diseases are not one-size-fits-all. Different patients may have varying underlying causes. Limited Understanding:  Our knowledge of the intricate biological pathways involved remains incomplete. Clinical Trial Challenges:  Identifying reliable biomarkers for early diagnosis and gauging treatment response is diffi...
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Re-Introduction

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WHY Drug Repurposing is NOT Enough

  📢      CALL for NEUROSCIENTISTS         📢 🔺     New drug development for #Alzheimer’s disease has a 99% failure rate… This MUST CHANGE If we are serious about tackling the impending GLOBAL BRAIN HEALTH CRISIS. ❌      Let’s face it, without a proactive approach to a brain healthy culture, the $2.5 trillion price tag per year in lost productivity will continue to increasingly balloon. This is increasingly taxing our health systems, our families, and compromising our ability to maintain sustainability economically and socially.  👉🏽      While there are multiple drug repurposing studies being conducted, many target the population as a whole. Inevitably , this results in some of the same limitations that traditional non-stratified drug development faces. 🔺      A part of this limitation revolves around the current research on Alzheimer’s not being representative of the world ...
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RE-POSITIONING the GAP between HEALTHSPAN and LIFESPAN… Over the five days of the Brain Matrix Alliance 's Innovation World Summit, a diverse range of cutting-edge technologies was explored, emphasizing advancements in brain health, longevity, and the emerging field of psychedelics. The summit featured in-depth discussions and presentations on: 🔶 Synergetic Interventions: exploration of two new scientific discoveries—Neuroplasticity and Epigenetics as the foundation for BRAIN HEALTH, LONGEVITY, PSYCHEDELICS 🟠 Neurotechnologies: Exploration of innovative technologies designed to enhance brain health, including neurostimulation, brain-computer interfaces, and neurofeedback systems. 🔷 Precision Medicine for Brain Health: Insights into personalized treatments for neurological conditions, leveraging genetic data and tailored interventions to optimize brain function. 🟡 Cognitive Enhancement Tools: Showcase of tools and applications aimed at enhancing cognitive abilities, from virtu...
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