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Brain GAP: The MISDIAGNOSIS

Brain GAP: The MISDIAGNOSIS  AUTHOR: KJ Lavan We are misdiagnosing the problem in brain health. Everyone is focused on innovation. New drugs. New biomarkers. Earlier detection. And yes, the science is moving fast. Lecanemab and donanemab have shifted Alzheimer’s care from symptom management toward disease modification in early-stage disease.  But 2025 appropriate-use recommendations for donanemab make clear that treatment requires biomarker confirmation, careful patient selection, MRI monitoring, and structured clinical pathways. ( ScienceDirect ) Blood-based biomarkers are also accelerating the field. A 2025  Nature Medicine  study showed that automated plasma p-tau217 testing can identify Alzheimer’s pathology with high accuracy, while also emphasizing the need for two-cutoff approaches across real-world settings. ( Nature ) A 2025  JAMA Neurology  cohort study of nearly 3,000 cognitively unimpaired individuals found that plasma p-tau217 can help identify...
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From Breakthroughs to Systems: The Missing Infrastructure in the Longevity Brain Economy

From Breakthroughs to Systems: The Missing Infrastructure in the Longevity Brain Economy AUTHOR: KJ Lavan We are entering a decisive decade for brain health, artificial intelligence, and longevity. Scientific breakthroughs have fundamentally reshaped what is possible: 🔺Blood-based biomarkers 🔺Predictive neurology 🔺AI-assisted diagnostics For the first time, we can: ☑️ detect ☑️ model ☑️ potentially intervene  …in cognitive decline  before it becomes irreversible . And yet, despite this progress, outcomes remain stubbornly constrained. Not by discovery. But by something far less visible. We are missing the infrastructure to implement what we already know. ⸻ The Illusion of Progress Across the global brain health ecosystem, momentum is undeniable: Research is accelerating Capital is mobilizing Policy attention is rising Innovation pipelines are expanding But beneath this surface, a structural disconnect is widening: ↳  Diagnostics are advancing faster than care pathways....
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