Resident T-Cells in Healthy Brains: A Paradigm Shift in Neuroimmunology
Here is a concise research brief summarizing the significance of the discovery of T cells in healthy brains and its implications for neuroinflammation and cognitive function research: Research Brief Title: Resident T Cells in Healthy Brains: A Paradigm Shift in Neuroimmunology Date: June 2025 Prepared for: Neuroscience and Immunology Research Stakeholders Author: KJ Lavan Background Historically, the brain has been viewed as an immune-privileged organ—largely insulated from systemic immune surveillance. T cells were thought to infiltrate the brain primarily during pathological events such as infections, trauma, or autoimmune diseases. However, new evidence (Source: The Subfornical Organ is a Nucleus for Gut-Derived T-Cells that Regulate Behavior, Yoshida, et al., Nature, 2025) reveals that T cells are not transient visitors but resident cells in healthy brains , raising critical questions about their function...