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Beyond Amyloid & Tau: Leveraging Molecular Subtypes and Repurposed Drugs for Personalized AD Treatment
CTAD 2024 Abstract Title : Beyon d Amyloi d & T au : Leveraging Molecular Subtypes and Repurposed Drugs for Personalized AD Treatment Au t hor : KJ Lavan , Brain Matrix Alliance, Dubai, UAE Background : Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Despite decades of research, there are currently only a handful of approved drugs, and none offer a cure. Traditional drug discovery for AD has a notoriously high 99% failure rate. This highlights the urgent need for new approaches. Stratified medicine, which tailors treatments to specific patient subgroups based on their unique molecular and genetic profiles, and drug repurposing, which leverages existing medications for new therapeutic uses, are emerging as promising strategies. Methods : While there are ongoing drug repurposing efforts in AD, these studies often target the entire patient population,...
Perennial Evolution” vs. “Fixed Mindsets” in the #scientific #medical #research #community
My recent post titled, “Mapping How #Ageing Affects Different Brain Cells,” raised a crucial point about the tension between maintaining a growth mindset and the often entrenched, fixed mindsets in various fields like medicine, pharmacology, and public health. In these domains, the pace of change in knowledge can sometimes be stifled by established norms, expert biases, and institutional inertia. The "illusion of skill" — where experts believe their knowledge is infallible or fully comprehensive — is a significant barrier to progress. To address these challenges and promote continuous growth and adaptability, I invite several approaches that could be antidotes: 🔺 Promoting a Culture of Humility in Science and Medicine Foster a learning culture : Cultivating humility among experts is crucial. The idea t...
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