Day 3 Interview with KJ Lavan on the Confluence of Epigenetics, Plant Me...
KJ Lavan presents a high-level perspective on the synergy of mental health, longevity, & psychedelics and the consequential benefits it can have for the world.
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Resident T-Cells in Healthy Brains: A Paradigm Shift in Neuroimmunology
Here is a concise research brief summarizing the significance of the discovery of T cells in healthy brains and its implications for neuroinflammation and cognitive function research: Research Brief Title: Resident T Cells in Healthy Brains: A Paradigm Shift in Neuroimmunology Date: June 2025 Prepared for: Neuroscience and Immunology Research Stakeholders Author: KJ Lavan Background Historically, the brain has been viewed as an immune-privileged organ—largely insulated from systemic immune surveillance. T cells were thought to infiltrate the brain primarily during pathological events such as infections, trauma, or autoimmune diseases. However, new evidence (Source: The Subfornical Organ is a Nucleus for Gut-Derived T-Cells that Regulate Behavior, Yoshida, et al., Nature, 2025) reveals that T cells are not transient visitors but resident cells in healthy brains , raising critical questions about their function...
Beyond Amyloid & Tau: Leveraging Molecular Subtypes and Repurposed Drugs for Personalized AD Treatment
CTAD 2024 Abstract Title : Beyon d Amyloi d & T au : Leveraging Molecular Subtypes and Repurposed Drugs for Personalized AD Treatment Au t hor : KJ Lavan , Brain Matrix Alliance, Dubai, UAE Background : Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Despite decades of research, there are currently only a handful of approved drugs, and none offer a cure. Traditional drug discovery for AD has a notoriously high 99% failure rate. This highlights the urgent need for new approaches. Stratified medicine, which tailors treatments to specific patient subgroups based on their unique molecular and genetic profiles, and drug repurposing, which leverages existing medications for new therapeutic uses, are emerging as promising strategies. Methods : While there are ongoing drug repurposing efforts in AD, these studies often target the entire patient population,...
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