WHY Drug Repurposing is NOT Enough

 📢     CALL for NEUROSCIENTISTS        📢


🔺  New drug development for #Alzheimer’s disease has a 99% failure rate…


This MUST CHANGE If we are serious about tackling the impending GLOBAL BRAIN HEALTH CRISIS.


❌   Let’s face it, without a proactive approach to a brain healthy culture, the $2.5 trillion price tag per year in lost productivity will continue to increasingly balloon. This is increasingly taxing our health systems, our families, and compromising our ability to maintain sustainability economically and socially. 


👉🏽   While there are multiple drug repurposing studies being conducted, many target the population as a whole. Inevitably , this results in some of the same limitations that traditional non-stratified drug development faces.


🔺   A part of this limitation revolves around the current research on Alzheimer’s not being representative of the world population. The challenge has been that for the most part, most of the genetic, economic data of Alzheimer’s (> 90%) has been generated from a very small set of the world population (Source: Martin et al., Biorxiv).


🔺   Excluding various factors that impact epidemiological transitions like race, ethnicity, region, cultures, etc. stifles efforts in deciphering the multi-factorial condition AD presents.


☑️    Brain Matrix Alliance’s current research is demonstrating that a stratified medicine approach to drug repurposing COULD reduce the failure rate of drug development in #Alzheimer’s by targeting drugs to susceptible populations. And thus, prevent beneficial drugs from being misclassified as failures.


👉🏽   Our research, in synergy with other research centers, thus far has uncovered several possibilities for stratification in AD (Alzheimer’s).

 

🚦   Although more research is required (a @BrainMatrixAlliance objective), in order to determine the optimal strategy to stratify the patient population and to identify future therapeutic targets, combining stratified medicine and drug repurposing strategies may be beneficial in AD.


🚀   We are on the brink of ushering in a new era of Alzheimer’s prevention over treatment (paradigm shift) that has the potential to change the brain health landscape in a highly “democratized” manner.


Let’s GO!


If you or someone you know would like to be a part of a potential paradigm shift by contributing your/their expertise in new drug discovery for AD…


Go to: thebm-worldsummit.com 


Our growing team looks forward to joining forces with you in helping to create a community built on unprecedented & insightful perspectives centered around evidence-based medicine. Ultimately, leading to AD prevention rather than treatment…


@alzheimerdrugdiscooveryfoundation @usagainstalzheimers @longevtysciencefoundation @alzheimerassociation @davosalzheimerscollaborative @europeanbraincouncil @nationalbrainfoundation @Federationof EuropeanNeuroscienceSocieties 

@NeuroscienceSociety @NationalBrainCouncil #research #medicine #clinicaltrials  @rudytanzi @curealzheimersfund @Societyforneuroscience (sfn) @A4LI

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