Day 3 Interview with KJ Lavan on the Confluence of Epigenetics, Plant Me...
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KJ Lavan presents a high-level perspective on the synergy of mental health, longevity, & psychedelics and the consequential benefits it can have for the world.
The Global Cognitive Resilience Economy: Dementia Policy, Prevention Economics, and the Infrastructure Architecture for 21st-Century Human Capital Stability AUTHOR: KJ Lavan A Davos-Ready Strategic Report (2026–2030) Prepared for: World Economic Forum World Health Organization United Nations Ministries of Health & Finance Sovereign Wealth Funds Multilateral Development Banks Institutional Investors Global Employers & Pension Systems ⸻ Executive Summary Dementia has entered a new strategic category. It is no longer solely a healthcare challenge, nor exclusively an aging issue. Dementia is emerging as a systemic macroeconomic stressor capable of reshaping labor markets, fiscal stability, healthcare infrastructure, intergenerational wealth transfer, and sovereign resilience over the coming decades.¹ Globally: More than 55 million people currently live with dementia¹ Prevalence is projected to exceed 139 million by 2050¹ Annual global economic burden already surpasses US...
By: KJ Lavan The Convergence of Astrocyte Biology, Metabolism, and Neuropsychiatric Health A lready quietly unfolding at the frontiers of neuroscience and precision medicine is the era of “metabo-neuro” interventions , and astrocytes are a key to unlocking it. 🔬 Why Astrocytes? Astrocytes are no longer seen as just "support cells" in the brain. They are: Metabolic gatekeepers – regulating glucose and lactate delivery to neurons. Neurotransmitter modulators – recycling glutamate, shaping synaptic transmission. Neuroimmune mediators – producing cytokines, responding to systemic inflammation. Circadian regulators – influencing sleep, feeding, and energy homeostasis. In essence, astrocytes translate metabolic cues into neural outcomes. 🔁 The Metabo-Neuro Feedback Loop There’s a bi-directional dialogue between metabolic health and brain health: Systemic metabolic dysfunction (e.g., insulin resistance, obesity) → astrocyte inflammation →...
Psychosocial Experiences and Human Brain Mitochondrial Biology: Emerging Evidence Linking Mind, Metabolism, and Neural Energy Systems (2024–2025) Author : KJ Lavan ⸻ Abstract Recent multidisciplinary research reveals that psychosocial experiences—ranging from chronic stress to purpose, meaning, and positive affect—are biologically embedded in human brain mitochondrial function. Mitochondria, long viewed as mere energy producers, are now recognized as dynamic transducers between psychological states and cellular energy metabolism. The present review synthesizes the most recent evidence, integrating 2024 PNAS postmortem brain proteomic findings with 2025 Nature Metabolism and Psychoneuroendocrinology stress-reactivity studies. Collectively, these data reveal that psychosocial experiences predict distinct patterns in mitochondrial oxidative phosphorylation (OxPhos) abundance, circulating mitochondrial biomarkers, and stress-sensitive endocri...
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